Table 1 The functional roles of m6A regulators in RNA metabolism.
From: The role of m6A modification in the biological functions and diseases
Type | M6ARegulator | Function | References |
|---|---|---|---|
m6A writer | METTL3 | Catalyzes m6A modification | |
METTL14 | Assists METTL3 to recognize the subtract | ||
METTL16 | Catalyzes m6A modification | ||
WTAP | Promotes METTL3-METTL14 heterodimer to the nuclear speckle | ||
KIAA1429 | Guides the methyltransferase components to specific RNA region | ||
RBM15 | Binds the m6A complex and recruit it to special RNA site | ||
ZC3H13 | Bridges WTAP to the mRNA-binding factor Nito | ||
m6A eraser | FTO | Removes m6A modification | |
ALKBH5 | Removes m6A modification | ||
m6A reader | YTHDC1 | Promotes RNA splicing and translocation | |
HNRNPA2B1 | Promotes primary microRNA processing | ||
HNRNPC | Mediates mRNA splicing | ||
YTHDF1 | Promotes mRNA translation | ||
YTHDF2 | Reduces mRNA stability | ||
YTHDF3 | Mediates the translation or degradation | ||
YTHDC2 | Enhances the translation of target RNA | ||
IGF2BP1/2/3 | Enhances mRNA stability |
