Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

Fig. 1

SIRT3 deletion in knockout mice does not induce cardiac hypertrophy. Body weight a and heart weight to tibia length (HW/TL) ratio b in SIRT3 knockout (KO SIRT3) mice and their wild-type (WT) littermates. c Representative hematoxylin and eosin stained micrographs showing transverse sections from the left ventricle myocardium and quantification of cardiomyocyte cross-sectional areas. d Relative quantification of Nppb (type B natriuretic peptide) and β-myosin heavy chain (β-MHC) mRNA expression. Graphs represent the quantification of adenine phosphoribosyl transferase (Aprt)-normalized mRNA levels expressed as a percentage of the WT samples. The data are the mean ± SD (Mann–Whitney test)

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