Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway

Fig. 1The alternative text for this image may have been generated using AI.

DCZ0858 inhibits DLBCL cell growth and proliferation. a Chemical structure of DCZ0858. b DLBCL cell lines (DB, TMD8, U2932, SUDHL-4, OCI-LY8, OCI-LY1, and NU-DUL-1) were treated with DCZ0858 at the indicated concentrations for 48 h. c NU-DUL-1 and OCI-LY8 were treated with DCZ0858 (2.5–40 μM) and processed at the indicated times. d PBMCs from three healthy volunteers and human B lymphocytes (WIL2-S) were treated with DCZ0858(10, 20, 40 μM) for 48 h. Cell viability was analyzed by CCK-8 assay. e Cell clone colonies formed by the NU-DUL-1 and OCI-LY8 cells treated with DCZ0858 (0, 20, and 40 μM); the colonies in each well were quantified (n = 3; *P < 0.05 and ***P < 0.001)

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