Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma

Fig. 1

a Transmission electron micrograph of exosomes from CCA and GBC patients. b Annotations of the exosomal small RNAs of normal individuals, CCA patients, and GBC patients. c Nucleotide preference of the exosomal small RNAs of normal individuals, CCA patients, and GBC patients. d Volcano map showing differentially expressed miRNAs in CCA- and GBC-derived exosomes. e Venn diagram showing overlapping differentially expressed miRNAs in CCA- and GBC-derived exosomes. f Expression levels of miR-96-5p, miR-151a-5p, miR-191-5p, and miR-4732-3p in plasma from 40 healthy individuals and 45 CCA patients. g ROC curve analysis for CCA diagnosis. Area under the curve (AUC) estimation for miR-96-5p, miR-151a-5p, miR-191-5p, and miR-4732-3p in CCA patients and healthy individuals. h Expression levels of miR-96-5p, miR-151a-5p, miR-191-5p, and miR-4732-3p in plasma from 45 CCA patients according to their tumor stage. i Changes in the plasma levels of miR-96-5p, miR-151a-5p, miR-191-5p, and miR-4732-3p in 45 CCA patients before (pre-Op) and 7 days after (7 days post-Op) surgical removal of the tumor

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