Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Targeting the premetastatic niche: epigenetic therapies in the spotlight

Fig. 1

Adjuvant epigenetic therapy (AET) disrupts the premetastatic niche (PMN) by inhibiting trafficking of monocytic myeloid-derived suppressor cells (MDSCs) and promoting their differentiation. Monocytic MDSCs from the bone marrow accumulate in the lung PMN before colonization by circulating tumor cells. AET results in a downregulation of CCR2, a key regulator of monocytic cell migration, which inhibits the migration of monocytic MDSCs into the lung. Additionally, AET promotes the differentiation of the monocytic MDSCs that manage to migrate to the PMN into a more interstitial macrophage-like phenotype, antagonizing their immunosuppressive and pro-tumor effects

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