Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Alternative splicing and cancer: a systematic review

Fig. 4

Oncogenic signal transduction driving alternative splicing in cancer. The RAS/RAF/ERK, PI3K/AKT and Wnt signaling pathways play an important role in regulating splicing factor via transcriptional regulation and/or post-translational modification, which lead to aberrant-splicing events that promote oncogenesis. P phosphorylation, Wnt Wingless, ERK extracellular signal regulated kinase, PI3K phosphatidylinositol 3-kinase

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