Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Alternative splicing and cancer: a systematic review

Fig. 5

Modulation of splicing as potential cancer therapeutics. Several representative strategies are depicted in the simplified splicing regulation diagram, including small molecules targeting the core spliceosome SF3b-complex compound, SSOs, ASO, short hairpin RNA interference/small interference RNA, clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) system, single-BEs (CBEs or ABEs) as well as antibodies against tumor-specific neo-antigen due to alternative splicing. SR serine/arginine-rich, ESE exonic splicing enhancer, ESS exonic splicing silencer, ISE intronic splicing enhancer, ISS intronic splicing silencer, SSOs splice-switching antisense oligonucleotides, ASO antisense oligonucleotide, BEs base editors, CBEs cytosine-BEs, ABEs adenine-BEs, CRISPR-Cas clustered regularly interspaced short palindromic repeats-Cas

Back to article page