Table 2 Diseases related to mis-spliced lncRNAs
Disease | Â | lncRNA | Mechanism | References |
|---|---|---|---|---|
Cancer | Breast | PNUTS | Related to hnRNP E1, regulate the metastatic potential of tumor cells | |
AML | HOXB-AS3 | Regulates ribosomal RNA transcription in NPM1-mutated AML | ||
Ovarian cancer | MALAT1 | Knockdown MALAT1 in ovarian cancer leads to reduced expression of RNA-binding protein fox-1 homolog 2 (RBFOX2) to inhibit tumor cell proliferation | ||
CRC (colorectal cancer) | MALAT1 | Releasing SFPQ from SFPQ / PTBP2 complex by binding to SFPQ to promote tumor growth and migration | ||
LINC01133 | Interacting with SRSF6 to inhibit the EMT and metastasis | |||
Lung | HOTAIR | Indicator of cell cycle dysregulation | ||
Adipogenesis |  | NEAT1 | Associates with SRp40 to regulate PPARγ2 Splicing | |
Retinal cell | Â | RNCR2 | Regulating retinal cell differentiation. | |
Prader-Willi syndrome | Â | SPA | Patterns of RBPs binding could be altered and alternative splicing. | |
Alzheimer | Â | 17A | Embedded in G-protein-coupled receptor 51 gene (GPR51), result the abnormal function of GABA B and alternative splicing |
