Table 2 The basic characteristics of PN GSCs and MES GSCs
From: The adaptive transition of glioblastoma stem cells and its implications on treatments
Difference | PN GSCs | MES GSCs |
|---|---|---|
Hallmarks | CD133, CD15, MAP2, SOX2, OLIG2, IDH1-mutant and EZH2 | CD44, ALDH1A3, EGFR, YKL40, IDH1-wildtype, BMI1 and GFAP |
Signaling pathways | The PDGF receptor-β mediated pathway; The Notch pathway; The Wnt pathway | The NF-κB pathway; FOXD-ALDH1A3 axis; glycolysis-mediated metabolism pathway |
Niche | Peri-vascular niche or tumor edge tissue | Necrotic tissue |
Lipid metabolism | Low | High |
Glutamine utilization | Low | High |
Metabolism preference | Glycolysis | Glycolysis or OXPHOS |
Immunocytes infiltration | Natural killer cells | M2 macrophage; CD8+ cells and microglial |
