Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation

Fig. 1

Small molecule BCL6 modulators and the binding mode of the BCL6 molecular glue. a Structure of BCL6 molecular glue BI-3802. b Structure of BCL6 inhibitor BI-3812. c Cyro-EM model of BCL6 filament with BI-3802 PDB code (6XMX). d Binding mode and key interaction made by BI-3802 (green) at the interface of BTBα (yellow), BTBβ (magenta), and BTBγ (orange) domains. e Structure of BCL6 PROTAC

Back to article page