Table 1 Dysregulated circRNAs that have been targeted in diseases
From: Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Related disease | circRNA ID | Dysregulation | Reference |
|---|---|---|---|
Cancer | |||
 Triple negative breast cancer (TNBC) | circAGFG1 | Up | |
 Breast cancer | circDnmt1 | Up | |
 Triple negative breast cancer (TNBC) | circHER2 | Up | |
 Triple negative breast cancer (TNBC) | circTADA2A-E6 | Down | |
 Breast cancer | Hsa_circ_0025202 | Down | |
 Hepatocellular carcinoma (HCC) | circβ-catenin | Up | |
 Hepatocellular carcinoma (HCC) | circRNA-104718 | Up | |
 Hepatocellular carcinoma (HCC) | circTRIM33-12 | Down | |
 Non-small cell lung cancer (NSCLC) | circRNA 100146 | Up | |
 Non-small cell lung cancer (NSCLC) | circPTPRA | Down | |
 Gastric cancer (GC) | circCACTIN | Up | |
 Gastric cancer (GC) | circPSMC3 | Down | |
 Gastric cancer (GC) | circHuR | Down | |
 Gastric cancer (GC) Colon cancer Prostate cancer Neuroblastoma | circAGO2 (hsa_circ_0135889) | Up | |
 Neuroblastoma | circCUX1 (hsa_circ_0132813) | Up | |
 Colorectal cancer (CRC) | circLONP2 (has_circ_0008558) | Up | |
Cardiovascular disease | |||
 Myocardial infarction (MI) | circNfix | Down | |
 Myocardial infarction (MI) | circTtc3 | Up | |
 Cardiac fibrosis (CF) | circHIPK3 | Up | |
 Cardiac fibrosis (CF) | circNFIB | Down | |
 Cardiac fibrosis (CF) | circYap | Down | |
 Doxorubicin–induced cardiomyopathy | circFoxo3 | Up | |
 Ischemia/reperfusion (I/R) | ACR | Down | |
 Cardiac hypertrophy | circSlc8a1 | Up | |
 Intimal hyperplasia | circ_Lrp6 | Up | |
Central nervous system disease | |||
 Alzheimer’s disease (AD) | CDR1as/ ciRS-7 | Down | |
 Acute ischemic stroke (AIS) | circHECTD1 | Up | |
 Acute ischemic stroke (AIS) | circTLK1 | Up | |
 Acute ischemic stroke (AIS) | circSCMH1 | Down | |
 Neuropathic pain | circAnks1a | Up | |
 Diabetes-related neuropathic pain | circHIPK3 | Up | |
 Neuropathic pain | circRNA.2837 | Down | |
 Depression | circHIPK2 | Up | |
 Blood–brain barrier (BBB) damage Acute ischemic stroke (AIS) Parkinson’s disease (PD) | circDLGAP4 | Down | |
Other diseases | |||
 Hepatic fibrosis | circPWWP2a (hsa_circ_0074837) | Up | |
 Pulmonary fibrosis | circHIPK3 | Up | |
 Diabetes-related retinal vascular dysfunction | circHIPK3 | Up | |
 Retinal vascular dysfunction Glaucoma | cZNF609 (mmu_circ_0001797) | Up | |
 Diabetes-related retinal vascular dysfunction | cPWWP2a | Up | |
 Osteoarthritis (OA) | circRNA.33186 | Up | |
 Osteoarthritis (OA) | circSERPINE2 (has_circ_0008365) | Down | |
 Intervertebral disc degeneration (IDD) | circRNA_104670 | Up | |
 Intervertebral disc degeneration (IDD) | circVMA21 | Down | |
 Bone nonunion | has_circ_0074834 | Down | |
