Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma

Fig. 6

Proposed mechanistic depiction of sorafenib resistance. The alleviated ROS responses in sorafenib-resistant HCC cells was due to decreased mitochondrial biogenesis. Mechanistic dissection indicated that upregulation of UBQLN1 in sorafenib-resistant HCC cells accelerated the protein degradation of PGC1β, contributing to the decreased mitochondrial biogenesis and ROS generation, finally inducing sorafenib resistance

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