Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection

Fig. 7

Schematic diagram of TAS2R138 involved lipid droplet degradation pathway. During P. aeruginosa infection, TAS2R138 competitively conjugated with PPARG antagonist AHL-12. The released PPARG redistributes from nuclear to cytoplasm to accelerate LDs degradation via binding with PLIN2. TAS2R138 binding with AHL-12 is associated with LDs, which is degraded during infection, thus helped the clearance of AHL-12 in neutrophils and promoting cell survival

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