Table 2 Slopes of decline in logit NR₂₀

Slope, per 10 day	coefficient	95% confidence interval	p-value for interaction
Days post onset			2 × 10⁻⁴
>60 days	−0.0735	−0.100 to −0.047
≤60 days	−0.132	−0.168 to −0.096
Age			0.041
>60 years	−0.106	−0.147 to −0.064
≤60 years	−0.132	−0.168 to −0.096
Peak logit NAb			0.034
>2.5	−0.158	−0.193 to −0.121
≤2.5	−0.132	−0.168 to −0.096
Gender			0.64
male	−0.126	−0.161 to −0.092
female	−0.132	−0.168 to −0.096

Slope of decline in logit NR₂₀ was estimated using a linear mixed effect model with random slope and random intercept. Modification of the slope by time window (≤60 days, >60 days post onset), age (≤60, >60 years), peak logit NR₂₀ level (≤2.5, >2.5), and gender (female, male) was evaluated by adding interaction terms in the model.

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