Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy

Fig. 1

PS exposure on the surface of colonic capillaries. a Normal C57BL/6 mice were received anti-PS antibody by tail vein injection. The sections of colon and rectum were stained for anti-PS antibody in green and MECA-32 in red. Representative images showed the staining of exposed PS co-localized with MECA-32. b Mice were injected intravenously with ANXA5-EGFP and anti-PS antibody. The sections of colon and rectum were prepared after 30 min of injection. Anti-PS antibody was stained in red with AF594-conjugated secondary antibody. The yellow in merged image indicate the co-location of ANXA5-EGFP and anti-PS antibody. c After intravenous injection of ANXA5-EGFP, the intestinal sections were prepared for TUNEL assay. Dnase I treatment as a positive control. Data are representative of more than three experiments (n = 3 mice/group). Scale bars: 100 μm. Arrows pointing to the co-location of dual fluorescences

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