Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy

Fig. 4

ANXA5, not A5m, alleviates TNBS-induced colitis. Mice with TNBS-induced colitis were treated with ANXA5 or A5m administration, respectively (n = 10 mice per group). Clinical features and severity were monitored by colon photographs (a), colon lengths (b), body weight loss (c), and disease activity index (DAI) (d). *P < 0.05; **P < 0.01 versus the model group according to Student’s t tests. #P < 0.05; ##P < 0.01 versus the corresponding A5m group at the same dosage according to Student’s t tests. e Representative images of colonic sections by H&E staining. f The inflammatory cytokines expressions of TNF-α, IL-6, and IL-18 in the serum (n = 5/group). Data are presented as means ± SD. *P < 0.05; **P < 0.01; ****P < 0.0001 versus the corresponding control group according to Student’s t tests

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