Fig. 1
From: Structure of serotonin receptors: molecular underpinning of receptor activation and modulation
Structural analysis of 5-HT1 receptor activation and modulation by lipids. a Structural model of 5-HT1A in complex with Gi and 5-HT in the ligand pocket, and with associated lipids (left). The structure–function relationships discovered on the basis of this and four other resolved structures (right). b Water molecules (W1–W4 shown in mesh) in the apo-5-HT1A ligand-binding pocket. Hydrogen bonds are shown with dashed lines. c Interactions of PtdIns4P at the 5-HT1A–Gi interface, with interacting residues shown in sticks. Hydrogen bonds are shown with dashed lines. d Side view of different TM7 conformations and TM7 interactions with aripiprazole and cholesterol between 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT1E. ECL1, extracellular loop 1. Reprinted by permission from Springer Nature: Nature, Xu et al. © (2021),1under exclusive licence to Springer Nature Limited.
