Fig. 1

Single-cell atlas and cell composition of recovered COVID-19 patients and healthy controls. a Sample collection time for four pregnant patients and six non-pregnant patients recovered from SARA-CoV-2 infection and the overall study design. Onset indicates the onset of COVID-19-related symptoms; RT-qPCR+ indicates days when subject’s PCR tested positive for SARS-CoV-2 in nasopharyngeal or sputum samples, while RT-qPCR− indicates the days when subjects tested negative for infection. Sampling indicates the days when the blood samples were collected for single-cell sequencing. SARS-CoV-2 antibody indicates the days when the donors tested positive for SARS-CoV-2-specific IgM and IgG. b Integrated UMAP graph of 172,988 cells derived from our study, color-coded by cell types. c Dot plot showing expression level of canonical cell markers used to assign cell identities. The color scale indicates the expression levels and the size of dots is proportional to the fraction of cells. d UMAP projection of the pregnant or non-pregnant donors. PHC pregnant healthy controls (blue), PCov pregnant COVID-19 patients (red), NHC non-pregnant healthy controls (green), NCov non-pregnant COVID-19 patients (orange). e Percentages of myeloid cells and lymphoid in PHC (n = 4), PCov (n = 4), NHC (n = 3), and NCov (n = 6), color-coded by groups. f Fraction of eight cell types in the sequenced cells. Box plots show median, interquartile range (IQR), and the whiskers corresponding to the highest and lowest points within 1.5 times of IQR. Each dot represents an individual. *p < 0.05, **p < 0.01. Wilcoxon rank-sum test, adjusted for Bonferroni post hoc