Fig. 6
From: Differential immune responses in pregnant patients recovered from COVID-19
Pregnant COVID-19 patients have elevated monocytic response. a Top GO terms and pathways enriched for DEGs in classical, intermediate, and non-classical monocyte from recovered COVID-19 patients compared to respective healthy controls. The color scale indicates adjusted p values derived from a hypergeometric test. The size of symbols is in proportion to gene counts enriched in the corresponding GO terms. Heatmaps of DEGs enriched in “response to interferon-gamma” (b) and “response to type I interferon” (c). d Box plots showing the levels of IFN-α, IFN-β, and IFN-γ in the plasma of patients and healthy donors. Box plots show median, interquartile range (IQR), and the whiskers corresponding to the highest and lowest points within 1.5 times of IQR. Each dot represents an individual. *p < 0.05, **p < 0.01, ****p < 0.0001, one-way ANOVA test, adjusted for Bonferroni post hoc test. e Expression level of FCGR3A in non-classical monocytes. *p < 0.05, ****p < 0.0001, Wilcoxon rank-sum test, adjusted for Bonferroni post hoc test. f Phagocytosis-related pathways enriched for DEGs from non-classical monocytes. The color scale indicates activation Z score (compared to related healthy controls) provided by Ingenuity Pathway Analysis and the sizes of symbols were proportional to –log10 (p value adjusted by Benjamini and Hochberg correction)
