Fig. 7
From: XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer
Scheme depicting the contribution of XBP1 in TAMs to colon cancer progression. a In the tumor microenvironment, activation of UPR/ER-XBP1 signaling in TAMs induced the production of cytokines, which inhibited macrophage phagocytosis of tumor cells via the disruption of self-recognition. Therefore, TAMs promote the metastasis of colorectal cancer. b Disabling UPR/ER-XBP1 signaling or treatment with anti-SIRPα antibodies may enhance anti-cancer capacity in a harsh tumor microenvironment
