Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment

Fig. 6

Overview of a mature T-cell synapse. The immunological synapses (IS) is also termed supramolecular activation complexes (SMACs), including the central region of the supramolecular activation complex (c-SMAC), the peripheral ring surrounding the c-SMAC (p-SMAC), the region distal to the synapse outside the p-SMAC (d-SMAC) and the molecules/ligand pairs that are found enriched within. Protein myristoylation makes a significant contribution to IS formation. APC antigen-presenting cell, CTLA4 cytotoxic T-lymphocyte antigen 4, ICAM1 intercellular adhesion molecule 1, LFA1 leukocyte function-associated antigen 1, PI3K phosphatidylinositol 3-kinase, SHP2 SRC homology 2-domain-containing protein tyrosine phosphatase 2, TCR T-cell receptor, ZAP70 ζ-chain-associated protein 70, LCK Src-family kinase

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