Table 4 Therapies targeting PI3K/Akt signaling
From: Targeting PI3K/Akt signal transduction for cancer therapy
Agent | Targets | Inhibitors |
|---|---|---|
Apoptosis | p53 | BKM120 |
CAL-101 | ||
GDC0068 | ||
p-S6 | BYL719 | |
GDC-0068 | ||
Rapamycin | ||
p38 | GSK2141795 | |
Proliferation | p53 | Bez235 |
Temsirolimus | ||
p-S6 | XL765 | |
XL147 | ||
GSK2121183 | ||
LY2780301 | ||
Rapamycin | ||
Deforolimus | ||
CDK1 | Everolimus | |
TGF-β1 | Bez235 | |
Autophagy | LC3B | MK2206 |
p-S6 | AZD5363 |
