Fig. 7: MC stabilizers prevent lung injury in mice.

a The illustration of mice treatment. C57BL/6N-Ace2^{em2(hACE2-WPRE,pgk-puro)/CCLA} mice were prior- administered with or without Eba. (5 mg/kg) or Lor. (10 mg/kg) via i.p. 1 day before intranasal infection with SARS-CoV-2 (strain 107) at a dose of 2 × 10⁶ TCID₅₀, and the Eba. and Lor. treatments were continued each day over the couse of infection. 5 mice for each treatment groups, and 2 mice without infection and drug treatment were used as the mock controls. Mice were euthanized and lung lobes were harvested for pathological analysis: Toluidine blue staining was used to observe MC degranulation, and the lung injury was observed via H.E. staining. Scale bar: 100 μm. h H.E. scores and (i) MC counts in lung section (5 dpi). *p < 0.05 and **p < 0.01 are considered significant differences