Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Proteomic and phosphoproteomic profiling of COVID-19-associated lung and liver injury: a report based on rhesus macaques

Fig. 1

Proteomic, phosphoproteomic, and bioinformatic analyses of rhesus macaques with COVID-19. a Brief workflow of this study. b KEGG enrichment analysis of differentially expressed proteins in the lung of control and virus-infected rhesus macaques. Red: upregulated. Blue: downregulated. c KEGG enrichment analysis of differentially expressed proteins in the liver of control and virus-infected rhesus macaques. Red: upregulated. Blue: downregulated. d, e Dominant pathways in the lung (d) and liver (e). Red boxes with black border: upregulated proteins in the infected tissue. Blue boxes with black border: downregulated proteins in the infected tissue. Pink boxes with pink border: kinases predicted to be activated in the infected tissue. White boxes: proteins in the pathway but not in the differentially expressed proteins. f Correspondence between the predicted kinases and FDA-approved drugs in DrugBank. Red marked drugs were predicted to work in both the lung and the liver. Red circles represent predicted activated kinases in the lung. Red and blue squares represent predicted activated and inhibited kinases in the liver, respectively

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