Fig. 5

NOXA expression is related to clinical outcomes after CAR T-cell infusion. a Representative images of immunohistochemical (IHC) staining for high and low NOXA expression in R/R B-cell lymphoma before treatment with tandem CD19/CD20 CAR T cells. The outlined areas in the left images are magnified on the right. Scale bars, 20 μm. b NOXA expression scores by IHC in responders and non-responders. A two-tailed Student’s t test was used to analyze the differences between two groups. c The ROC curve of NOXA IHC scores in responders and non-responders. d The number of responders and non-responders in the low NOXA expression group and high NOXA expression group. A Fisher’s exact test was used for analysis. e, f Kaplan–Meier plot of progression-free survival and overall survival in the low NOXA expression group and high NOXA expression group. Log-rank tests were used to analyze the significance between the two groups. g–k Baseline characteristics of patients and transfused CAR T cells between two groups, including tumor burden, lymphoma type, CAR T-cell dose, CD4/CD8 ratio, and memory phenotype Two-tailed Student’s t test were used to analyze the differences between two groups. Values are shown as the mean ± SD. ns: not significant (P > 0.05); *P < 0.05, **P < 0.01, and ***P < 0.001