Fig. 2

Viral load in rhesus macaques challenged with Beta variant B.1.351. Nasal swab, trachea, bronchus, lung LN, BALs, and lung lobe specimens were collected at the time shown in Fig. 1a. a–g SARS-CoV-2 gRNA and sgRNA levels were measured by RT-PCR and expressed as viral copies. LLOD refers to a low level of detection. gRNA was quantified in nasal swabs (a), BALs (c), a mixture of 6 lung lobes (d), trachea/bronchus/lung LN/each lung lobe (g). sgRNA was quantified in nasal swabs (b), BALs (e), and a mixture of six lung lobes (f). One spot represents one animal. *p < 0.05, **p < 0.01