Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2

Fig. 6

TRIM47 modulates endothelial activation through NF-κB and MAPK signaling pathways. Representative images of the immunoblots of p-IκBα, IκBα, p-IKKα/β, IKKα, IKKβ, p-p65, p65, TIRM47, and β-actin after TNFα stimulation detected by western blot and the relative quantitation of the protein levels in (a) TRIM47-knockdown and (b) TRIM47-overexpressed HUVECs. Representative images of the immunoblots of p-ERK, ERK, p-JNK, JNK, p-p38, and p38 after TNFα stimulation detected by western blot and the relative quantitation of the protein levels in (c) TRIM47-knockdown and (d) TRIM47-overexpressed HUVECs (n = 3, one-way ANOVA, *P < 0.05, **P < 0.01)

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