Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation

Fig. 2

Quantitative proteomics revealed cell cycle progression through activation of cell cycle related proteins promoted by DHA. a The principal component analysis (PCA) at the proteomics level for a total of six spleen samples of the DHA- and CMC- gavage mice. b Differentially expressed proteins were displayed by volcano plots. The vertical lines correspond to 1.5-fold up and down, respectively, and the horizontal line represents the P-value cut-off of 0.05. Upregulation of protein expression in DHA group is shown in red, while downregulation is shown in blue. c KOG classifications of differentially expressed proteins (DEPs). The ordinate denotes the number of proteins in each KOG category. d A bubble chart showing the KEGG pathways. The bubble size represents the number of DEPs, and the bubble color represents the p value. e The pathway map showed the different key proteins involved in the cell cycle signaling pathways. DHA=dihydroartemisinin group, CMC=CMC (carboxymethyl cellulose) solvent solution control group

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