Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

Fig. 2

Mutations and their effect on SARS-CoV-2 spike protein. a Structural overview of SARS-CoV-2 spike protein and its subdomain RBD and NTD. Mutations from variants were marked beside the colored surface. b Patterns of mutational impact on the spike protein. Mutations affect the spike affinity to ACE2 and neutralizing antibodies (nAbs) and influence the spike protein conformations. BioRender is used to generate the structural presentation and cartoon models. Pymol is used to generate the surface model of RBD or NTD region. 6VSB, 7CM4, and 6M0J structures are retrieved from PDB database

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