Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Comparative characterization of antibody responses induced by Ad5-vectored spike proteins of emerging SARS-CoV-2 VOCs

Fig. 2

Binding and neutralizing antibodies induced by Ad5-vectored SARS-CoV-2 variant vaccines. BALB/c mice (n = 10 per group) received a single intramuscular immunization with Ad5-B.1.1.7, Ad5-B.1.351, Ad5-P.1, Ad5-B.1.429, Ad5-B.1.617.1, B.1.617.2, Ad5-WT or Ad5-null. a Immunization schedule of Ad5-vectored SARS-CoV-2 variant vaccines. IgG binding antibodies against S of WT (b), B.1.351 (c) and B.1.617.2 (d) were detected by ELISA at 28 days post-immunization, and the neutralizing antibody titers against WT (e) and the B.1.351 (f) and B.1.617.2 (g) variants were obtained through the microneutralization assay and listed in the table (h). The bar graphs show the geometric mean values, and the data of the Ad5-null control group are not shown because all of them were seronegative. The statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons tests. The NAbs against WT, B.1.351 and B.1.617.2 in serum from 25 convalescent patients (i) and Ad5-WT immunized mice (j) were used to compare the difference in neutralizing activity between convalescent sera and vaccinated mice sera

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