Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Comparative characterization of antibody responses induced by Ad5-vectored spike proteins of emerging SARS-CoV-2 VOCs

Fig. 5

Pseudovirus neutralizing antibodies induced by Ad5-WT-prime and variant vaccine-booster vaccination. Sera of mice were collected at 28 days post-booster immunization. The PNAb titers against the WT strain (a) and the B.1.351 (b), B.1.617.2 (c), B.1.1.7 (d), P.1 (e) and B.1.617.1 (f) variants in different variant vaccine groups were obtained. The statistical significance among different groups was determined by one-way ANOVA with Tukey’s multiple comparisons tests. The PNAb GMTs to a certain type of pseudovirus were normalized by dividing by the highest value of PNAb GMT to the matched pseudovirus in all booster groups. The broad-spectrum neutralization abilities of the vaccine strategy involving boosting with Ad5-WT (g), Ad5-B.1.1.7 (h), Ad5-B.1.351 (i), Ad5-P.1 (j), Ad5-B.1.429 (k), Ad5-B.1.617.1 (l), and B.1.617.2 (m) and the overall picture (n) are shown

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