Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing

Fig. 3

Ligand–receptor interactions between different immune cell types in LUAD and LUSC. a Chord plot summarizing interconnections between different immune cell types from LUAD and LUSC. Lines represent potential interconnections between cell types, with line thickness proportional to the number of ligand–receptor pairs expressed in the connected cell types. b The molecular interaction pairs of different immune cell type interaction pairs in LUAD and LUSC, and the molecule pair marker in red showing the LUAD and LUSC specific molecular pairs. c Dot plot showing the expression of the tumor subtype specific ligands and receptors in each cell type. The color and size indicate the effect size. d The expression of specific ligands and receptors in LUAD and LUSC. Bubble size represents the ratio of LUAD/LUSC based on the expression. e, f Dot plot showing the mean expression level and percentage of selected interaction pairs involved in IL-17, T-cell receptor, PD-L1 expression and the PD-1 checkpoint pathway and angiogenesis. The expression of each gene was considered separately for each sample source

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