Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: SLC7A11: a new regulator in diabetic wound healing

Fig. 1

Boosting efferocytosis improves diabetic wound healing via targeting SLC7A11 in dendritic cells (DCs). a SLC7A11 acts as brake on DC efferocytosis, which was revealed by RNA-seq in DCs during efferocytosis. b Interfering with SLC7A11 function affected wound healing dynamics by erastin co-administering early-stage apoptotic cells in vivo. c Efferocytosis in DCs enhanced via glycogenolysis with inhibition or knockout of SLC7A11 in vitro. d SLC7A11 inhibition at the wound site can boost diabetic wound healing by improving apoptotic cell clearance and GDF15 secretion. Created with BioRender.com

Back to article page