Table. 2 Current clinical trials targeting activation or inhibition of thermogenic fat in humans

From: The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

Type of therapy	Pharmacologic agent	Study participants	Phase	Status	Trials ID
Pro-browning
β3-AR agonist	Mirabegron	Healthy volunteers	I	Recruiting	NCT01950520
	Mirabegron	Healthy volunteers	Not applicable	Completed	NCT02811289
	Mirabegron	Healthy volunteers	I	Recruiting	NCT03049462
	Mirabegron	Healthy volunteers	I/II	Not yet recruiting	NCT04766021
	Mirabegron	Healthy volunteers	Not applicable	Recruiting	NCT04823442
	Mirabegron	Healthy volunteers	II	Completed	NCT01783470
	Mirabegron	People with obesity	I	Completed	NCT02919176
	Ephedrine	Healthy volunteers	Not applicable	Completed	NCT01015794
	Ephedrine and caffeine	People with obesity	III	Completed	NCT02048215
	Ephedrine and pioglitazone	Healthy volunteers	Not applicable	Recruiting	NCT02236962
Thyroid hormones	Levothyroxine	Patients with thyroidectomy	Not applicable	Completed	NCT02499471
	Levothyroxine	Healthy volunteers	IV	Recruiting	NCT01379170
	Liothyronine	Patients with insulin receptor mutation	II	Completed	NCT02457897
Capsaicinoids	Capsinoids	Healthy volunteers	Not applicable	Not yet recruiting	NCT02964442
	Capsinoids	People with obesity	Not applicable	Completed	NCT03110809
	Capsinoids	Healthy volunteers	Not applicable	Completed	NCT01961674
GLP1	Liraglutide	People with obesity	III	Not yet recruiting	NCT02718950
	Liraglutide	People with T2DM	IV	Terminated	NCT01638260
	Liraglutide	People with obesity	III	Not yet recruiting	NCT02718950
	Bydureon	Healthy volunteers	IV	Recruiting	NCT03002675
	Bydureon	People with obesity	III	Completed	NCT00856609
	Sitagliptin	People with impaired glucose tolerance	IV	Completed	NCT02294084
Other agents	Bromocriptine	Healthy volunteers	Not applicable	Completed	NCT02428933
	Nicotinic acid	People with T2DM or not	Not applicable	Recruiting	NCT05092945
	Creatine	People with a vegetarian diet	Not applicable	Completed	NCT04086381
	L-arginine	People with impaired glucose tolerance	III	Recruiting	NCT02291458
	Adenosine	Healthy volunteers	Not applicable	Completed	NCT03327168
	Fluvastatin	Healthy volunteers	IV	Completed	NCT03189511
	Niagen	Healthy volunteers	Not applicable	Completed	NCT02835664
Anti-browning
Anti-thyroid drug	CMZ or TMZ	Patients with Graves’ disease	Not applicable	Not yet recruiting	NCT03064542
Glucocorticoids β3-AR blocker	Prednisone	Healthy volunteers	IV	Completed	NCT03269747
	Propranolol	Healthy volunteers	Not applicable	Completed	NCT01791114
	Propranolol	People with hyperthyroidism	IV	Completed	NCT03379181
	Propranolol	Healthy volunteers	II	Recruiting	NCT01950520

β3-AR β3-adrenergic receptor, GLP1 glucagon-like peptide 1, T2DM type 2 diabetes mellitus, CMZ carbimazole, TMZ thiamazole, Niagen nicotinamide riboside.

Back to article page

Table. 2 Current clinical trials targeting activation or inhibition of thermogenic fat in humans

Search

Quick links