Fig. 4
From: Epigenetic regulation of aging: implications for interventions of aging and diseases
Chromatin structural remodeling during aging. A general loss of heterochromatin and detachment of lamina-associated domain (LAD) structures from the nuclear lamina occur during this process. Higher-order chromatin structure alterations during aging are accompanied by the redistribution of various histone modifications, including histone methylation (H3K4me3, H3K27me3, H3K36me3, H3K9me3) and acetylation (H3K9ac, H3K56ac, H4K16ac, H3K18ac). This leads to reactivation of repeating sequences and dysregulated gene expression due to aberrant chromatin accessibility
