Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation

Fig. 1

Temporal transcriptomic characterization of AST in KL mouse model. a Representative H&E staining and immunohistochemistry (IHC) photos of KL mouse lungs at a series of time points after Ad-Cre nasal inhalation, ranging from 4 weeks (4 W) to 10 weeks (10 W). 4W-7W were ADC and 8W-10W were SCC. Normal lung (NL) were used as control. Scale bar: 50 µm. b RNA-seq analyses of KL lung lesions at a series of time points. Relative expression of canonical ADC and SCC marker genes were depicted. c Principal component analyses (PCA) of RNA-seq data revealing the trajectory of phenotypic transitions from benign tissue to ADC to SCC. Each node represented one sample, with the number indicating the time points (weeks) of sampling. 0 indicated NL. d Transcriptional dynamics of ADC markers (Nkx2-1, Napsa) and SCC markers (Trp63, Sox2) on the same PCA embedding as c. Node colors reflected the relative expression of each marker gene

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