Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation

Fig. 3

Inactivation of the Wnt pathway promotes the AST process in KL mouse model. a The Kras LSL-G12D/+; Lkb1flox/flox (KL, n = 24) and Kras LSL-G12D/+; Lkb1flox/flox; Ctnnb1flox/flox (KLC, n = 12) mice were given Ad-Cre via nasal inhalation and histologically analyzed at 8 weeks afterwards. b Representative H&E staining on KL and KLC mouse lung tumors. SCC lesions were indicated. Scale bar: 1 mm. c Representative H&E staining and p63 immunohistochemical staining on KL and KLC mouse lung tumors. SCC lesions were indicated. Scale bar: 500 µm. d Representative β-catenin immunohistochemical staining on KL and KLC mouse lung tumors. Scale bar: 50 µm. e SCC incidence of KL and KLC mice at 8 weeks post Ad-Cre treatment. Tumor No. = Tumor number, w SCC = with SCC, w/o SCC = without SCC. f. Average ADC and SCC numbers of KL and KLC mice at 8 weeks post Ad-Cre treatment. ****P < 0.0001

Back to article page