Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy

Fig. 1The alternative text for this image may have been generated using AI.

Timeline depicting the brief history of interferon discovery and key events about STING biology since its identification in 2008. ATG16L1, autophagy-related 16 like 1; CDN cyclic dinucleotides, cGAMP cyclic GMP–AMP, CRISPR/Cas9 clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9, ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1, ERIS endoplasmic reticulum IFN stimulator, IFN interferon, IRF1 interferon regulatory factor 1, IRF3 interferon regulatory factor 3, LPS lipopolysaccharide, MITA mediator of IRF3 activation, PERK PKR-like endoplasmic reticulum kinase, STING stimulator of interferon genes, TALEN transcription activator-like effector nucleases, TBK1 TANK-binding kinase 1, TLR4 Toll-like receptor 4, SAVI STING-associated vasculopathy with onset in infancy

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