Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy

Fig. 7

The schematic diagram showing the underlying mechanisms involved in mitophagy repression by CRL4CUL4A/DDB1 in chemoresistant ovarian cancer. Downregulation of CRL4CUL4A/DDB1 promotes mitophagy by modulating the Parkin-PINK1 axis, MFF phosphorylation, DRP1Ser637 dephosphorylation, as well as the interaction between DRP1 and VDAC1, eventually inducing mitochondrial fission and selectively removing fragmented mitochondrial in chemoresistant ovarian cancer cells. [created with BioRender.com (https://biorender.com/)]

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