Fig. 11 | Signal Transduction and Targeted Therapy

Fig. 11

From: The sirtuin family in health and disease

Fig. 11The alt text for this image may have been generated using AI.

The roles of SIRTs in respiratory system. SIRTs are involved in common respiratory diseases including COPD, asthma, lung fibrosis, COVID-19, and other lung injured diseases. SIRT1, SIRT3 and SIRT6 play protective effects in COPD, and these three members also have a positive effect on asthma. However, SIRT2 and SIRT7 could aggravate the occurrence of asthma. In lung fibrosis, the positive effects of SIRT1, SIRT3, SIRT6 and SIRT7 have been demonstrated. Besides, SIRT3 and SIRT6 contribute to the remission of lung injury, whereas SIRT1 play dual effects on the disease. Moreover, the activation of SIRT1 can effectively alleviate ventilator or paraquat-induced lung injury. Finally, SIRTs are also associated with COVID-19. https://biorender.com

Back to article page