Fig. 2

Overview of the roles of SIRTs in inflammation. a SIRTs mainly play an anti-inflammatory effect by regulating inflammatory mediators, however, early inhibition of SIRT2 may prevent neuroinflammation evidenced by reduced levels of GFAP, IL-β, IL-6, and TNF-α; (b) SIRTs could negatively regulate several pro-inflammatory cytokines; (c) SIRTs are involved in the regulation of NF-κB signaling pathway. https://biorender.com. ABCA1 ATP‑binding cassette A1, ABCG1 ATP‑binding cassette G1, Arf alternative reading frame, CaMKKβ Ca(2 + )/calmodulin-dependent protein kinase kinase β, CCR7 C‑C chemokine receptor type 7, CRIF1 CR6-interacting factor1, CTLA4 cytotoxic T lymphocyte–associated antigen 4, CTRP1 C1q/tumor necrosis factor-related protein 1, DBC1 deleted in breast cancer 1, DEPTOR DEP-domain containing mTOR-interacting protein, DMP1 dentin matrix protein-1, Ebi3 Epstein-Barr virus–induced gene 3, FGF21 fibroblast growth factor 21, FXR farnesoid X receptor, GFAP glial fibrillary acidic protein, HIF-α hypoxia-inducible factor-alpha, HMGB1 high-mobility group box 1, HNF4α hepatocyte nuclear factor 4α, HO1 heme oxygenase-1, ICOS inducible T cell co-stimulator, IFN-γ interferon-γ, IKKβ inhibitor kappa B kinaseβ, IRAK interleukin-1 receptor-associated kinase, IRF9 interferon regulatory factor 9, LXR liver X receptor, MCP monocyte chemotactic protein, MCPIP1 MCP-1 induced protein, MIP-2 macrophage inflammatory protein-2, MKP-1 mitogen-activated protein kinase phosphatase-1, NT5C3A pyrimidine 5'-nucleotidase, PAI-1 plasminogen activator inhibitor-1, PARP-1 peroxisome proliferator-activated receptor 1, PGRN progranulin, RORγt RAR-related orphan receptor γ-t, TAK1 transforming growth factor β activated kinase-1, TM thrombomodulin, VCAM-1 vascular cell adhesion molecule-1, XBP1 X-box binding protein 1