Fig. 6
Overview of the roles of SIRTs in autophagy. SIRTs can regulate a series of substrates involved in the process of macroautophagy and mitophagy. Meanwhile, they can also be regulated by a series of molecules in the aforementioned process. SIRTs are all involved in the regulation of macroautophagy, of which AMPK/mTOR signaling is the most common pathway. In addition, SIRT1, SIRT3, SIRT4, and SIRT5 are also involved in PINK1/Parkin-mediated mitophagy or Bnip3-mediated mitophagy. https://biorender.com. ACE2 angiotensin-converting enzyme 2, ATGL adipose triglyceride lipase, Bnip3 BCL2 interacting protein 3, CERKL ceramide kinase-like protein; circ, circular RNA; CUL4B, cullin 4B, eEF2 eukaryotic elongation factor-2, eEF2K eukaryotic elongation factor-2 kinase, EGFR epidermal growth factor receptor, ESRRA estrogen-related receptor α, FBXW7 F-box and WD repeat domain-containing 7, FoxM1 forkhead box M1, G6Pase-α glucose-6-phosphatase-α, GAS5 growth arrest specific 5, Hes‑1 hairy and enhancer of split‑1, HIF1α hypoxia-inducible factor 1 α, HIST1H1C histone cluster 1 H1 family member c, IPMK inositol polyphosphate multikinase, LDHB lactate dehydrogenase B, lncR long non-coding RNA, miR miRNA, NAT10 nucleolar protein N-acetyltransferase 10, NMNAT1 nicotinamide mononucleotide adenylyltransferase 1, Notch‑1 Notch homolog 1, OPA1 optic atrophy 1, p53 tumor protein p53, PINK PTEN induced putative kinase, PLIN5 perilipin 5, PTEN phosphatase and tensin homolog, SQSTM1/p62 sequestosome 1, TFEB transcription factor EB, TUG1 taurine-upregulated gene 1, TyrRS tyrosyl transfer-RNA synthetase, Ube2v1 ubiquitin-conjugating E2 enzyme variant 1
