Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Signaling pathways in brain tumors and therapeutic interventions

Fig. 2

Signaling pathways, genetic mutations, as well as targeted treatment are implicated in glioma development. Tumorigenesis in glioma is activated through diverse mechanisms. Molecular alteration with clinically significant (such as MGMT, IDH, BRAF) eventually converges to several crucial signaling pathways (EGFR, PTEN, VEGF, MET, PI3K/AKT/mTOR, WNT, and TGF-β), resulting in tumor proliferation, invasion, cell survival, and immune evasion. “P” labeling is attached to the molecules that are phosphorylated due to signaling transduction. Created with BioRender.com (https://biorender.com) and Reactome pathway database (https://reactome.org/)

Back to article page