Fig. 8 | Signal Transduction and Targeted Therapy

Fig. 8

From: MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1

Fig. 8

Transcriptomics analysis of the wound tissue and confirmation experiment of the inflammation signaling pathways. a Volcano plot of differentially expressed genes (DEGs) at day 3 and day 7. b Venn diagram of two overlapping circles representing the overlapped down and up genes at day 3 and day 7. c Gene Ontology (GO) enrichment analysis of DEGs. d DEGs at day 7 were enriched in skin development and differentiation. e KEGG pathway enrichment analysis of DEGs. f SGM-miR146a-Exo@SFP upregulated insulin pathway and cell adhesion molecule (CAM) pathway at day 7. g The expressions of p-NFκB-p65, NFκB-p65, p-IκBα, and IκBα in wound tissue. Data represent the mean ± S.D. of three different experiments (ns, no significance, *p < 0.05, **p < 0.01, ***p < 0.001)

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