Fig. 5
From: Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment
TP lipo alleviates severe pulmonary inflammation by reducing pulmonary recruitment of the Macro-Saa3 cell subset and increasing pulmonary residency of the AM cell subset. a UMAP plot of 13 subsets of myeloid cells colored by cluster identity. b UMAP plots showing the dynamic changes in the myeloid cell clusters among each group. c Ratio of all cells belonging to the myeloid cell clusters. d Violin plots showing the smoothed expression distribution for selected inflammation-related marker genes for each group. Red, high expression; yellow, low expression. e Differential interaction strength of significant ligand-receptor pairs between any pair of two cell populations. The edge width was proportional to the indicated strength of ligand-receptor pairs. Blue edge, weakened cellular communication; Red edge, strengthened cellular communication. f, g The cytokine score (f) and inflammatory score (g) of myeloid cell subsets from Blank controls, Model, Vehicle lipo, and TP lipo groups. h, i Five inflammatory-related pathway scores of Macro-Saa3 (h) and AM (i) among Blank controls, Model, Vehicle lipo, and TP lipo groups. Significance is indicated by: ns no significance; **P ≤ 0.01; ***P ≤ 0.005; ****P ≤ 0.0001
