Fig. 3
From: COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy
Similar cytokine profiles in COVID-19-associated encephalitis and SARS-CoV2-induced lung and liver injury. a Inflammation analysis of differentially expressed proteins in brain tissues from patients diagnosed with COVID-19 vs. controls. Columns on the left of the heatmap represent different inflammatory factors. The right of the heatmap lists gene names. Red and blue boxes indicate normalized intensity of the enriched or depleted proteins, respectively. Histogram shows the ratio of protein intensities from the COVID-19 patients. Y-axis represents the log2 COVID-19/Controls. b Immunohistochemistry shows endothelial cells, lymphocytes, and monocytes positive for IL-4, IL-6, IL-8, IL-12, TGF- β, and TNF-α. c The similarities of inflammatory factors in the brain, lung, and liver tissues of COVID-19 patients
