Table 1 Clinical information of COVID-19 patients

From: COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy

 

Case 1

Case 2

Case 3

Case 4

Case 5

Case 6

Case 7

Case 8

Case 9

Sex

M

M

F

F

F

M

M

F

F

Age

77

87

57

87

84

59

68

80

59

Course (days)

18

11

29

38

21

55

52

62

49

Medical history

DM

Hypertension

CAHD

Healthy

Healthy

Hypertension, Cavavar cerebral infarction, Brain atrophy, Atherosclerosis

DM

DM

DM

Hypertension

DM

Initial and subsequent symptoms

Fever, chivering, progressive expiratory dyspnea

Asthma, cough, both lower limbs scattered in spots

Fever, cough, anorexia, diarrhea

Fever, cough, pain in the throat, oppression in the chest, dyspnea

Fever, dry cough,

body muscle soreness, vomiting

Fever, cough,

oppression in the chest

Fever, cough, wheezy, bad appetite

Fever, cough

Fever, cough,

oppression in chest

Neurological symptoms

Disturbance of consciousness, coma

Disturbance of consciousness,

restlessness deep coma

Disturbance of consciousness, out of spirit, abnormal gait, deep coma

Coma

Out of spirit, abnormal gait, mild disturbance of consciousness, headache

Out of spirit, tension and anxiety, deep coma

Out of spirit, abnormal gait, deep coma

Out of spirit, abnormal gait, disturbance of consciousness, deep coma

Out of spirit,

abnormal gait

Bacterial infection

(culture)

Klebsiella

(blood)

No

(blood)

A. baumannii,

P. aeruginosa,

E. coli, Klebsiella

(blood)

No

(blood)

No

(blood)

A. baumannii,

P. aeruginosa,

Klebsiella

(sputum)

No

(blood)

P. aeruginosa

A. baumannii

(BALF)

No

(blood)

Main diagnoses and the causes of death

1. COVID-19 (critical)

2. Respiratory failure

3. Renal insufficiency

1. COVID19 (critical)

2. Septic shock

3. Respiratory failure

4. Lacunar cerebral infarction

1. COVID-19 (critical)

2. Septic shock

3. ARDS

4. Bacterial pneumonia

5. Massive airway hemorrhage

1. COVID-19 (critical)

2. Respiratory failure

3. Heart failure

1. COVID-19 (critical)

2. Renal insufficiency

3. Bacterial pneumonia

4. Respiratory failure

5. Multiple cerebral infarction

1. COVID-19 (critical)

2. ARDS

3. Bacterial pneumonia

4. Renal insufficiency

1. COVID-19 (critical)

2. Septic shock

3. ARDS

1. COVID-19 (critical)

2. Lung cancer

3. Lacunar cerebral infarction

4. Bacterial pneumonia

5. ARDS

1. COVID-19 (critical)

2. ARDS

3. Septic shock

4. Renal insufficiency

  1. CAHD coronary atherosclerotic heart disease, DM diabetes mellitus, COPD chronic obstructive pulmonary disease, ARDS acute respiratory distress syndrome, BALF bronchoalveolar lavage fluid, ESBLs extended-spectrum β-lactamases