Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes

Fig. 4

Interaction between VCP and DICAR in the pyroptosis of cardiomyocytes induced by AGEs. a Representative images of VCP pulled down by DICAR probe and detected by CHIRP-MS. b Total VCP protein expression between WT and db/db mice. c RIP used to detect the combination between VCP and DICAR. d Model prediction of VCP combined with DICAR. e the KD of DICAR combined with VCP detected by SPR. f the effect of VCP-siRNA on anti-pyroptosis induced by AGEs. Data are represented as mean ± SEM. **P < 0.01, ***P < 0.001 vs. con; ++P < 0.01 vs. AGEs (200 µg/ml, 48 h); ##P < 0.01 vs. AGEs +mDICAR-JP, n = 4

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