Fig. 2
From: Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Four different epigenetic regulatory mechanisms. The figure presented DNA methylation, histone modification, chromatin remodelling, and ncRNAs. DNA methylation is a universal chemical modification by which methyl groups (Me) are added to the DNA molecule, usually happening on the CpG islands. Histone undergoes several different post-translational modifications, including acetyl (Ac), Me, phosphate (P) and ubiquitin (Ub). Chromatin remodelling complexes change the packaging state of chromatin by moving, sliding, disrupting, or restructuring the nucleosome. ncRNAs are participated in multiple physiological and pathological process by targeting different molecules. This figure was generated with Servier Medical Art (https://smart.servier.com/)
