Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation

Fig. 7

RNF5 expression level is negatively correlated with the severity of the disease caused by SARS-CoV-2. The mRNA level a and protein level b of RNF5 from samples of PBMC cells and lung tissues of young and older people were determined by RT-qPCR and IB analysis. Results shown are one representative from three independent repeats. c The mRNA level of RNF5 from samples of PBMC cells of mild or severe COVID-19 patients was determined by RT-qPCR. Statistical significance was analyzed using two-sided unpaired t tests (*p < 0.05, ***p < 0.001)

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